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SWOG S1712

Status:

Recruiting | Phase II

Official Title:

A randomized phase II study of ruxolitinib (NCS-752295) in combination with BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia (CML) patients with molecular evidence of disease.  

Study Purpose:

The purpose of this study is to compare the good and bad effects of adding the study drug ruxolitinib to the usual chemotherapy (called TKI, which is either dasatinib or nilotinib) with the good and bad effects of using TKI alone.

Interventions:

  • ARM I:  Receive single agent TKI for up to one year.
  • ARM II:  Receive single agent TKI and ruxolitinib for up to one year.

Patients will be followed for up to 5 years from initial randomization.

Key Participation Requirements:

Gender:

Male or Female

Age:

19 years and older

Diagnosis:

Chronic myeloid leukemia (CML) with BCR-ABL in your blood.

Eligibility:

Patients must be receiving treatment with dasatinib or nilotinib as first or second line therapy for a minimum of 6 months prior to registration.

Patients must not be receiving any other investigational agents.

Patients must sign an approved informed consent and authorization permitting release of personal health information.

Methodist Health System Trial Code:

SWOG S1712

For more information, visit the U.S. National Library of Medicine clinical trial database.

To learn more about this clinical trial please contact us today!