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Gastrointestinal Cancer Trials

The following listings are our current trials. If you have questions or want to learn more about the trial, please contact us and provide the Methodist Health System Trial Code listed with the description.

Alliance A021502

Status: Recruiting | Phase III 

Official Title: Testing the Addition of the Antibody Atezolizumab to Usual Chemotherapy after Surgery in Patients with Colon Cancer

Study Purpose: The purpose of this study is to compare any good and bad effects of using the drug atezolizumab along with the usual chemotherapy compared to the usual chemotherapy alone. Learn more

Alliance A021602

Status: Recruiting | Phase III

Official Title: Testing cabozantinib in patients with advanced pancreatic neuroendocrine and carcinoid tumors after progression on everolimus

Study Purpose: The purpose of this study is to learn if treatment with a drug called cabozantinib to prevent tumor growth is better, the same, or worse than placebo (a pill that contains no active drug). Learn more.

Alliance A021703

Status: Recruiting | Phase III

Official Title: Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients with Previously Untreated Metastatic Colorectal Cancer (Solaris)

Study Purpose: To compare amount of time to until the cancer advances in patients receiving high-dose vitamin D3 in combination with standard chemotherapy (FOLFOX or FOLFIRI) and bevacizumab against patients receiving standard-dose vitamin D3 in combination with standard chemotherapy and bevacizumab. Learn more.


Status: Recruiting | Phase II

Official Title: Testing the Addition of the Drug Nivolumab after Surgery for High Risk Anal Cancer

Study Purpose: To find if adding the study drug, nivolumab (also known as OPDIVO), after standard chemotherapy and radiation will prevent the anal cancer from returning. Learn more. 


Status: Recruiting | Phase II

Official Title: Study Lower-Dose Chemoradiation for Early-Stage Anal Cancer

Study Purpose:  To compare lower-dose chemoradiation therapy to standard-dose chemoradiation therapy and to find out if this approach is better or worse than the usual approach for anal cancer. Learn more. 


Status: Recruiting | Phase II

Official Title: Testing the Combination of Pevonedistat With Chemotherapy For Bile Duct Cancer Of The Liver.

Study Purpose:  To determine if the study drug, pevonedistat alone or pevonedistat in combination with carboplatin and paclitaxel is more efficient in shrinking your cancer. Learn more. 

BeiGene BGB-A317-305

Status: Recruiting | Phase II

Official Title: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Clinical Study Comparing the Efficacy and Safety of Tislelizumab (Bgb-A317) Plus Platinum and Fluoropyrimidine versus Placebo Plus Platinum and Fluoropyrimidine as First-Line Treatment in Patients with Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Study Purpose: The overall purpose of this study is to compare the effects and safety, of tislelizumab plus chemotherapy to placebo (an inactive substance) plus chemotherapy on you and your Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (GC/GEJ) to find out the most effective treatment. Learn more

Novocure PANOVA-3

Status: Recruiting | Phase III 

Official Title: Pivotal, randomized, open-label study of Tumor Treating Fields (TTFields 150kHz) concomitant with gemcitabine and nab-paclitaxel for front-line treatment of locally-advanced pancreatic adenocarcinoma

Study Purpose: The purpose of this study is to evaluate the efficacy and safety of TTFields together with standard chemotherapy (gemcitabine and nab-paclitaxel) compared to standard chemotherapy (gemcitabine and nab-paclitaxel) without TTFields. Learn more

Pharmatech Lilly J1L-AM-JZGB

Status: Available | Phase III

Official Title: A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared with FOLFOX Alone as Second-line Therapy in Patients with Metastatic Pancreatic Cancer that has Progressed During or Following a First-Line Gemcitabine Containing Regimen

Study Purpose: To determine if an investigational drug, AM0010, in combination with an approved chemotherapy regimen, FOLFOX (oxaliplatin plus 5-fluorouracil (5-FU) plus leucovorin), is safe and effective in the treatment of patients with metastatic pancreatic cancer that has progressed during or following a first-line Gemcitabine containing regimen, compared with FOLFOX alone. Learn more

Pharmatech QBGJ398-301

Status: Available | Phase III

Official Title: A Phase 3 Multicenter, Open-Label, Randomized, Controlled Study of Oral Infigratinib versus Gemcitabine with Cisplatin in Subjects with Advanced/Metastatic or Inoperable Cholangiocarcinoma with FGFR2 Gene Fusions/Translocations: The PROOF Trial

Study Purpose: The PROOF Trial is a clinical research study to determine if the investigational drug, infigratinib, is an effective treatment for cholangiocarcinoma compared with the standard of care, chemotherapy gemcitabine with cisplatin, for patients with a genetic abnormality in the Fibroblast Growth Factor Receptor (FGFR) gene. Learn more

SWOG S1613

Status: Recruiting | Phase II

Official Title: Testing combination antibody treatment with Trastuzumab and Pertuzumab for advanced or metastatic colorectal cancer

Study Purpose: To compare any good or bad effects of using a combination of antibodies, Trastuzumab and Pertuzumab, to treating with the usual chemotherapy, Cetuximab and Irinotecan. Learn more

SWOG S1815

Status: Recruiting | Phase III

Official Title:  A Phase III Randomized Trial Of Gemcitabine, Cisplatin, And Nab-Paclitaxel Or Gemcitabine And Cisplatin In Newly Diagnosed Advanced Biliary Tract Cancers

Study Purpose: The primary purpose of this study is to compare the effects of adding the drug nab-paclitaxel to the standard of care drugs cisplatin and gemcitabine versus cisplatin and gemcitabine alone. The study wants to find out which treatment approach is better for newly diagnosed advanced biliary tract cancers. Learn more


Status: Suspended | Phase III

Official Title: Testing Combination Chemotherapy with or without an Investigational Drug or the Investigational Drug Alone for Metastatic Colon or Rectal Cancer

Study Purpose: To learn if adding the experimental agent atezolizumab (MPDL3280A) to the usual treatment or giving the experimental agent alone is better than the usual treatment alone for metastatic colon or rectal cancer. Learn more


Status: Recruiting | Phase II/III

Official Title: Using Cancer Cells In the Blood (Ctdna) To Predict If Chemotherapy Will Benefit Patients Who Have Surgery for Early Stage Colon Cancer

Study Purpose: To learn if a ctDNA test done after your surgery for colon cancer is helpful to decide if you should receive chemotherapy. Learn more