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Head and Neck Cancer Trials

The following listings are our current trials. If you have questions or want to learn more about the trial, please contact us and provide the Methodist Health System Trial Code listed with the description.

AbbVie M19-894

Status: Recruiting | Phase IB

Official Title: A Phase 1B, Multicenter, Open-Label Study To Determine The Safety, Tolerability, Pharmacokinetics, And Preliminary Efficacy Of Abbv-368 Plus Tilsotolimod And Other Therapy Combinations In Subjects With Recurrent/Metastatic Head And Neck Squamous Cell Carcinoma

Study Purpose: To evaluate the effect the combination therapies have on the patient’s body and the tumor activity and use biomarker tests and imaging results to determine the effects of the combination therapy the patients are assigned to . Learn more. 

Checkmate Pharmaceuticals CMP-001-007

Status: Pending | Phase II

Official Title: A Multicenter Phase 2, Open Label Study Of Intratumoral CMP-001 In Combination With Intravenous Pembrolizumab In Subjects With Recurrent Or Metastatic Head And Neck Squamous Cell Carcinoma

Study Purpose: To determine the safety and efficacy of the study drug, CMP-001, when given in combination with pembrolizumab. Learn more


Status: Recruiting | Phase II

Official Title: Testing The Addition Of Chemotherapy Drug, Cisplatin, To Usual Radiation Therapy For Patients With Head And Neck Cancer

Study Purpose: The purpose of this study is to compare two treatment approaches currently used after surgery for head and neck cancer. One approach is to administer radiation therapy alone.  A second approach is to administer radiation therapy along with the chemotherapy drug, cisplatin. Learn more

Exelixis XL184-311

Status: Recruiting | Phase III 

Official Title: A phase 3, randomized, double-blind, placebo-controlled study of cabozantinib (XL184) in subjects with radioiodine-refractory differentiated thyroid cancer who have progressed after prior VEGFR-targeted therapy

Study Purpose: The purpose of this study is to evaluate the effect of cabozantinib compared with placebo on progression free survival (PFS) and objective response rate (ORR) in subjects with Radioiodine-Refractory Differentiated Thyroid Cancer (DTC) who have progressed after prior VEGFR-Targeted therapy. Learn more

MECC HN01 - HPV De-escalated Protocol

Status: Recruiting | Phase: Not Applicable

Official Title: De-escalation Protocol of HPV Mediated Oropharyngeal Squamous Cell Carcinoma Based on the American Joint Committee on Cancer Care (AJCC) 8th Edition Staging Manual

Study Purpose: The purpose of this study is to evaluate the effects of treating patients with Human Papilloma Virus (HPV) positive head and neck cancer with less treatment based on the updated head and neck cancer staging system. Learn more.


Status: Recruiting | Phase II and III

Official Title: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

Study Purpose: To compare the standard treatment for nasopharyngeal cancer with the drug combination gemcitabine and paclitaxel to see if patients do better and live longer.  This is also testing if directing treatment using a blood test to look for the Epstien Bar Virus will result in patients doing better and not needing as much treatment. Learn more.


Status: Recruiting | Phase III

Official Title: Testing The Addition Of An Anti-Cancer Immune Therapy Drug (Nivolumab) To The Usual Chemo Therapy Treatment (Cisplatin Or Carboplatin With Gemcitabine) For Recurrent Or Metastatic Nasopharyngeal Cancer.

Study Purpose: To compare the usual chemotherapy, cisplatin (or carboplatin) and gemcitabine alone to the usual chemotherapy plus an immune therapy drug, nivolumab. Learn more.

RTOG 1008

Status: Recruiting | Phase II

Official Title: A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors

Study Purpose: To compared the effects of radiation and chemotherapy with radiation alone on patients with salivary gland cancer that was removed surgically to find out which is better at reducing the risk of the cancer coming back. Learn more.

RTOG 1216

Status: Recruiting | Phase II/III 

Official Title: Randomized phase II/III trial of surgery and postoperative radiation delivered with concurrent cisplatin versus docetaxel versus docetaxel and cetuximab for high-risk squamous cell cancer of the head and neck

Study Purpose: The purpose of this study is to find out what effects, good and/or bad, treatment has on you and your cancer.  Learn more