left-arrow right-arrow pinterest facebook google_plus linkedin

MECC HN01 - HPV De-escalated Protocol


Recruiting | Phase: NA

Official Title:

De-escalation Protocol of HPV Mediated Oropharyngeal Squamous Cell Carcinoma Based on the American Joint Committee on Cancer Care (AJCC) 8th Edition Staging Manual

Study Purpose:

HPV positive head and neck cancer has been shown to respond very well to treatment and, as a result, the head and neck cancer staging system was updated to better reflect how HPV cancers respond to treatment.  The purpose of this study is to evaluate the effects of treating patients with Human Papilloma Virus (HPV) positive head and neck cancer with less treatment based on the updated head and neck cancer staging system.


  • Treatments on this study can involve surgery, radiation or chemotherapy.  May receive just one of those treatments or a combination of treatments based on the stage of the disease.  This will be determined by your doctor and the Nebraska Methodist Multidisciplinary Tumor Board.
  • Study agents: Cisplatin
  • Quality of Life questionnaires

After completion of study therapy, patients are followed for as long as the study remains active.   

Key Participation Requirements:


Male or Female


19 years and older


HPV positive Squamous Cell Carcinoma of the tonsils, base of tongue, or oropharyngeal cavity


Must have HPV positive head and neck cancer.

Patients must sign an approved informed consent and authorization permitting release of personal health information.

Methodist Health System Trial Code:

HPV De-escalated Protocol

To learn more about this clinical trial please contact us today!